Not miRly a Knockout
نویسندگان
چکیده
منابع مشابه
Knockout! Knockout! Who’s Not There?
The deeper we look at human genomes, the more unexpected things we find. And increasingly we are surprised by what each of us lacks. In particular, in recent years we have learned that naturally occurring human gene knockouts are prevalent. The results of the Exome Aggregation Consortium (ExAC) now paint a rich and detailed picture of gene redundancy and essentiality in humans (Lek et al., 2016...
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To the Editor: In a recent issue of Circulation, Hoorntje et al1 presented data on a family with a duplication in exon 4 of HERG. A consanguineous marriage resulted in 2 homozygous offspring: one died before birth and the other had a severe cardiac phenotype characterized by arrhythmias and conduction defects. The importance of these findings regarding the role of HERG in the heart is clear. Th...
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We consider the problem of using simulation to efficiently estimate the win probabilities for participants in a general random knockout tournament. Both of our proposed estimators, one based on the notion of “observed survivals” and the other based on conditional expectation and post-stratification, are highly effective in terms of variance reduction when compared to the raw simulation estimato...
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Opioid peptides long have been hypothesized to play a role in ethanol reinforcement. Neuropharmacological studies have shown that opioid receptor antagonists decrease ethanol self-administration in rodents and prevent relapse in humans. However, the exact mechanism for such powerful effects has remained elusive. The availability of mu-opioid receptor knockout mice has made possible the direct e...
متن کاملm-Opioid Receptor Knockout Mice Do Not Self-Administer Alcohol
Opioid peptides long have been hypothesized to play a role in ethanol reinforcement. Neuropharmacological studies have shown that opioid receptor antagonists decrease ethanol selfadministration in rodents and prevent relapse in humans. However, the exact mechanism for such powerful effects has remained elusive. The availability of m-opioid receptor knockout mice has made possible the direct exa...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2011
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2011.08.010